Spatial orientation of cross-sectional images of coronary arteries: point of view in intracoronary imaging

<p>Abstract</p> <p>Background</p> <p>In studies where cross-sectional images of coronary arteries obtained with different imaging modalities are compared, the importance of correct co-localization and matching of images along the coronary artery longitudinal axis is obvious. However, it appears neglected that correct spatial orientation of the cross-sectional plane may not be obtainable just by rotating the images to ensure co-localization of identifiable landmarks such as sidebranches. A cross-section has two sides, one facing proximally and the other distally, and pairs of images reconstructed corresponding to these opposite points of view are mirror images of each other and not superimposable. This may be difficult if not impossible to recognize and unrecognized it will give rise to flawed results in the development and validation of imaging technologies aimed at plaque characterization (tissue mapping). We determined the imagined point of view for three commercially available intracoronary imaging systems used by invasive cardiologists and illustrate its importance in imaging modality validation.</p> <p>Methods and Results</p> <p>We made an asymmetric phantom and investigated it with two different intravascular ultrasound (IVUS) systems and one optical coherence tomography (OCT) system. The asymmetry of the phantom allowed determination of the spatial orientation of the cross-sectional images. On all tested systems, an observer should imagine herself/himself standing proximal to the cross-section when looking at the intravascular images.</p> <p>Conclusions</p> <p>The tested intracoronary imaging modalities displayed cross-sectional images with a spatial orientation corresponding to a proximal point of view. Knowledge of the spatial orientation is mandatory when comparing and validating different imaging modalities aimed at plaque characterization.</p

Faint BVRI Photometric Sequences in Selected Fields

The results from work done to extend the Johnson-Cousins BVRI photometric standard sequence to faint levels of V ~ 21 mag in compact fields is presented. Such calibration and extension of sequences is necessary to fill a calibration gap, if reliable photometry from modest aperture telescopes in space (e.g. HST), or terrestrial telescopes with apertures exceeding 4-m is to done. Sequences like the ones presented here, which cover a large range in brightness as well as color, will allow photometric calibration to be done efficiently, as well as for such work to be less prone to systematic sources of error. Photometry of stars in approximately 10 x 10 arc-minute fields around 3 globular clusters, NGC 2419, Pal 4 and Pal 14 are presented. In each field, several stars are measured in B, V, R and I passbands, with standard errors less than 0.015 mag from random errors, to levels fainter than V=21 mag. The primary context for the work presented here is that parts of these fields were observed repeatedly by the Wide Field Planetary Camera-2 WFPC2) of the HST, and thus these newly calibrated sequences can be used to retroactively calibrate WFPC2 at over various times of its operating life. The sequences presented here agree at the 0.02 mag level with other extant calibrations of these targets, except in the I band, where there are color dependent deviations of up to 0.05 mag versus one other photometric sequence. Possible causes for this discrepancy are examined.Comment: 56 pages, 14 figures, 14 table

Cepheid Distances to SNe Ia Host Galaxies based on a Revised Photometric Zero-Point of the HST-WFPC2 and New P-L Relations and Metallicity Corrections

With this paper we continue the preparation for a forthcoming summary report of our experiment with the Hubble Space Telescope (HST) to determine the Hubble constant using type Ia supernovae as standard candles. Two problems are addressed. (1) We examine the need for, and determine the value of, the corrections to the apparent magnitudes of our program Cepheids in the eleven previous calibration papers due to sensitivity drifts and charge transfer effects of the HST WFPC2 camera over the life time of the experiment from 1992 to 2001. (2) The corrected apparent magnitudes are applied to all our previous photometric data from which revised distance moduli are calculated for the eight program galaxies that are parents to the calibrator Ia supernovae. Two different Cepheid P-L relations are used; one for the Galaxy and one for the LMC. These differ both in slope and zero-point at a fixed period. The procedures for determining the absorption and reddening corrections for each Cepheid are discussed. Corrections for the effects of metallicity differences between the program galaxies and the two adopted P-L relations are derived and applied. The distance moduli derived here for the eight supernovae program galaxies, and for 29 others, average 0.20 mag fainter (more distant) than those derived by Gibson et al. and Freedman et al. in their 2000 and 2001 summary papers for reasons discussed in this paper. The effect on the Hubble constant is the subject of our forthcoming summary paper.Comment: 73 pages, 16 figures, 8 tables, accepted for publication in the Astrophysical Journa

Cepheid Calibration of the Peak Brightness of SNe Ia. X. SN 1991T in NGC 4527

Repeated imaging observations have been made of NGC 4527 with the Hubble Space Telescope between April and June 1999, over an interval of 69 days. Images were obtained on 12 epochs in the F555W band and on five epochs in the F814W band. The galaxy hosted the type Ia supernova SN1991T, which showed relatively unusual behavior by having both an abnormal spectrum near light maximum, and a slower declining light curve than the proto-typical Branch normal SNe Ia. A total of 86 variables that are putative Cepheids have been found, with periods ranging from 7.4 days to over 70 days. From photometry with the DoPHOT program, the de-reddened distance modulus is determined to be (m-M)_0 = 30.67 +/- 0.12 (internal uncertainty) using a subset of the Cepheid data whose reddening and error parameters are secure. A parallel analysis of the Cepheids using photometry with ROMAFOT yields (m -M)_0 =30.82 +/- 0.11. The final adopted modulus is (m -M)_0 =30.74 +/- 0.12 +/- 0.12 (d=14.1 +/- 0.8 +/- 0.8 Mpc). The photometric data for SN1991T are used in combination with the Cepheid distance to NGC 4527 to obtain the absolute magnitude for this supernova of M_V^0(max) = -19.85 +/- 0.29. The relatively large uncertainty is a result of the range in estimates of the reddening to the supernova. Thus SN1991T is seen to be only moderately brighter (by ~ 0.3 mag) than the mean for spectroscopically normal supernovae, although magnitude differences of up to 0.6 mag cannot be ruled out.Comment: 46 pages, LATEX using aaspp4.sty, including 9 embedded tables, 19 figures (gif and jpg files), a full-resolution version (ps files) is available at http://www.astro.unibas.ch/forschung/ll/cepheid.shtml, accepted for publication in the Astrophysical Journa

Terahertz oscillations in an In_0.53Ga_0.47As submicron planar gunn diode

The length of the transit region of a Gunn diode determines the natural frequency at which it operates in fundamental mode – the shorter the device, the higher the frequency of operation. The long-held view on Gunn diode design is that for a functioning device the minimum length of the transit region is about 1.5μm, limiting the devices to fundamental mode operation at frequencies of roughly 60 GHz. Study of these devices by more advanced Monte Carlo techniques that simulate the ballistic transport and electron-phonon interactions that govern device behaviour, offers a new lower bound of 0.5μm, which is already being approached by the experimental evidence that has shown planar and vertical devices exhibiting Gunn operation at 600nm and 700nm, respectively. The paper presents results of the first ever THz submicron planar Gunn diode fabricated in In&lt;sub&gt;0.53&lt;/sub&gt;Ga&lt;sub&gt;0.47&lt;/sub&gt;A on an InP substrate, operating at a fundamental frequency above 300 GHz. Experimentally measured rf power of 28 µW was obtained from a 600 nm long ×120 µm wide device. At this new length, operation in fundamental mode at much higher frequencies becomes possible – the Monte Carlo model used predicts power output at frequencies over 300 GHz

The Universal Initial Mass Function In The XUV Disk of M83

We report deep Subaru Halpha observations of the XUV disk of M83. These new observations enable the first complete census of very young stellar clusters over the entire XUV disk. Combining Subaru and GALEX data with a stellar population synthesis model, we find that (1) the standard, but stochastically-sampled, initial mass function (IMF) is preferred over the truncated IMF, because there are low mass stellar clusters (10^{2-3}Msun) that host massive O-type stars; that (2) the standard Salpeter IMF and a simple aging effect explain the counts of FUV-bright and Halpha-bright clusters with masses >10^3Msun; and that (3) the Halpha to FUV flux ratio over the XUV disk supports the standard IMF. The Subaru Prime Focus Camera (Suprime-Cam) covers a large area even outside the XUV disk -- far beyond the detection limit of the HI gas. This enables us to statistically separate the stellar clusters in the disk from background contamination. The new data, model, and previous spectroscopic studies provide overall consistent results with respect to the internal dust extinction (Av~0.1 mag) and low metallicity (~0.2Zsun) using the dust extinction curve of SMC.Comment: 11 pages, 8 figures. Accepted for publication in Ap

Dynamical mass of a star cluster in M83: a test of fibre-fed multi-object spectroscopy

(Abridged) Aims: We obtained VLT/FLAMES+UVES high-resolution, fibre-fed spectroscopy (FFS) of five young massive clusters in M83 (NGC 5236). This forms the basis of a pilot study testing the feasibility of using FFS to measure the velocity dispersions of several clusters simultaneously, in order to determine their dynamical masses; Methods: We adopted two methods for determining the velocity dispersion of the star clusters: cross-correlating the cluster spectrum with the template spectra and minimising a chi^2 value between the cluster spectrum and the broadened template spectra. Cluster 805 in M83 was chosen as a control to test the reliability of the method, through a comparison with the results obtained from a standard echelle VLT/UVES spectrum obtained by Larsen & Richtler; Results: We find no dependence of the velocity dispersions measured for a cluster on the choice of red giant versus red supergiant templates, nor on the method adopted. We measure a velocity dispersion of sigma_los = 10.2+/-1.1 km/s for cluster 805 from our FFS. Our FLAMES+UVES velocity dispersion measurement gives M_vir = (6.6+/-1.7)e5 M_sun, consistent with previous results. This is a factor of ~3 greater than the cluster's photometric mass, indicating a lack of virial equilibrium. However, based on its effective star formation efficiency, the cluster is likely to virialise, and may survive for a Hubble time, in the absence of external disruptive forces; Conclusions: We find that reliable velocity dispersions can be determined from FFS. The advantages of observing several clusters simultaneously outweighs the difficulty of accurate galaxy background subtraction, providing that the targets are chosen to provide sufficient S/N ratios, and are much brighter than the galaxy background.Comment: 10 pages, 4 figures, accepted by A&

Cepheids and Long Period Variables in NGC 4395

Repeated imaging observations of NGC 4395 were made with the WIYN 3.5 m and the KPNO 2.1 m telescopes. From the photometry of the resolved brighter stars in this galaxy eleven Cepheids with periods ranging between 12 and 90 days have been identified. The true distance modulus has been derived from the apparent distance moduli in g, r and i. The distance modulus is 28.02 +/- 0.18 based on the LMC P-L relation by Sandage et al. 2003; this corresponds to a distance of 4.0 +/- 0.3 Mpc. Using the P-L relation from Madore & Freedman 1991, the distance modulus is 28.15 +/- 0.18; which corresponds to a distance of 4.3 +/- 0.4 Mpc. The reddening is calculated to be E(g-r) = 0.06 +/- 0.08 and E(r-i) = 0.10 +/- 0.08, again from the distance moduli mu_g, mu_r and mu_i. In addition, 37 other variables have been detected, the majority of which have definite periods. They are probably all red long period variables.Comment: 54 pages, 8 figures, 8 tables, accepted for publication in the Astronomical Journa